Connect the dots

Secondary & associated conditions

One service-connected condition often leads to others. If you have one of the conditions below, look closely at the ones commonly associated with it. A Nexus Letter is what connects them with medical evidence.

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How secondary service connection works

These are the VA's own rules. The medical evidence has to show the link — that is exactly what a Nexus Letter does.

Caused by a service-connected condition

A disability that is proximately due to or the result of a service-connected condition is itself service connected. 38 CFR § 3.310(a)

Made worse by a service-connected condition

If a non-service-connected condition is aggravated by a service-connected one, the added disability can be service connected. 38 CFR § 3.310(b)

Weight gain as the “intermediate step”

Obesity is not a disability by itself, but VA recognizes it can be the link — for example, a back condition limits activity, weight gain follows, and sleep apnea or hypertension develops. VA General Counsel Precedent Opinion 1-2017

TBI: conditions VA presumes are secondary

After a service-connected TBI, VA presumes these are secondary when timing and severity criteria are met: Parkinsonism, unprovoked seizures, certain dementias, depression, and hormone deficiency diseases. 38 CFR § 3.310(d)

If you have this, think about these

If you were Airborne, rucked, or ran hard

Knees, hips, ankles & back

Consider:

  • Osteoarthritis of the knees, hips, and ankles
  • Lumbar and cervical degenerative disc disease
  • Radiculopathy (sciatica) secondary to a back condition
  • The opposite knee or hip, from years of favoring the injured side
  • Depression secondary to chronic pain
  • Stomach and kidney problems from long-term anti-inflammatory (NSAID) use
The evidence

Active-duty service members were diagnosed with osteoarthritis at 7.86 per 1,000 person-years, and service members 40 and older had 19 times the rate of those 20 and younger. Cameron et al., Arthritis & Rheumatism, 2011

Prolonged load carriage is linked to stress fractures, back strains, knee pain, metatarsalgia, and rucksack palsy. Knapik et al., Military Medicine, 2004

Veteran military parachutists showed more knee and ankle joint changes than comparison groups. Murray-Leslie et al., Annals of the Rheumatic Diseases, 1977

If you have PTSD, depression, or anxiety

Mental health conditions

Consider:

  • Obstructive sleep apnea
  • Erectile dysfunction (from the condition or its medications)
  • Hypertension and heart disease
  • GERD and irritable bowel syndrome
  • Migraines and tension headaches
  • Bruxism and TMJ
  • Substance use disorder
The evidence

69.2% of Iraq and Afghanistan veterans in a VA PTSD clinic screened high-risk for sleep apnea, and higher PTSD severity increased that risk. Colvonen et al., Journal of Clinical Sleep Medicine, 2015

PTSD raised the risk of sexual dysfunction more than threefold (adjusted RR 3.61), and 4.59 with psychiatric medication. Breyer et al., Journal of Sexual Medicine, 2014

A meta-analysis found PTSD is associated with an increased risk of coronary heart disease. Edmondson et al., American Heart Journal, 2013

If you have type 2 diabetes

Diabetes (including Agent Orange)

Consider:

  • Peripheral neuropathy — each arm and each leg is rated separately
  • Diabetic retinopathy and cataracts
  • Diabetic kidney disease
  • Erectile dysfunction
  • Hypertension and coronary artery disease
  • Peripheral vascular disease
The evidence

Neuropathy, retinopathy, and kidney disease are recognized diabetes complications that the American Diabetes Association directs clinicians to screen for routinely. ADA Standards of Care in Diabetes — 2025

If you were exposed to Agent Orange

Agent Orange presumptives & their complications

Consider:

  • Every complication of type 2 diabetes listed above
  • Complications of ischemic heart disease
  • Erectile dysfunction and urinary incontinence after prostate cancer treatment
  • Conditions secondary to Parkinson’s disease
  • Hypertension, hypothyroidism, and MGUS — now presumptive
The evidence

The presumptive condition gets you in the door; the complications are claimed as secondary. See our PACT Act page for the full presumptive list and qualifying locations.

If you have a traumatic brain injury

TBI

Consider:

  • Depression, Parkinsonism, seizures, dementia, and hormone deficiency diseases (VA-presumed when criteria are met)
  • Chronic headaches and migraines
  • Sleep disturbance
  • Tinnitus
  • Cognitive and memory problems
The evidence

VA regulation presumes specific conditions are secondary to service-connected TBI, including depression within 3 years of a moderate or severe TBI or within 12 months of a mild TBI. 38 CFR § 3.310(d)

If you have tinnitus or hearing loss

Tinnitus

Consider:

  • Anxiety
  • Depression
  • Insomnia and sleep disturbance
  • Headaches
The evidence

Among U.S. veterans with tinnitus, 38% also had a depression diagnosis, and nearly 70% of people seeking tinnitus treatment report insomnia. Patil et al., Frontiers in Aging Neuroscience, 2023

If you have sinus or breathing problems

Chronic sinusitis & rhinitis

Consider:

  • Obstructive sleep apnea
  • Chronic headaches
  • Asthma (presumptive for burn pit exposure when diagnosed after discharge)
The evidence

People with nighttime nasal symptoms five or more nights a month were 1.8 times more likely to have moderate-to-severe sleep-disordered breathing. Young et al., Journal of Allergy and Clinical Immunology, 1997

If a service-connected condition led to weight gain

Weight-related conditions

Consider:

  • Obstructive sleep apnea
  • Hypertension
  • Type 2 diabetes
  • Knee and hip arthritis
The evidence

VA allows obesity to be the intermediate step between a service-connected condition and a secondary one, when the medical evidence shows the chain. VA General Counsel Precedent Opinion 1-2017

This page is educational information, not a guarantee of service connection. Every claim depends on the veteran’s own medical evidence. A Nexus Letter reviews your specific records and gives a medical opinion on whether the link is supported.

See what may apply to you

Our free readiness check looks at your conditions and flags secondary connections worth a closer look.

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Still have questions? Request a call from Dr. Clinton

References

  1. 38 CFR § 3.310 — Disabilities that are proximately due to, or aggravated by, service-connected disease or injury. eCFR
  2. VA Office of General Counsel, Precedent Opinion 1-2017 (Jan. 6, 2017), Service Connection Based on Obesity. VA.gov (PDF)
  3. Cameron KL, et al. Incidence of physician-diagnosed osteoarthritis among active duty United States military service members. Arthritis & Rheumatism. 2011. Wiley
  4. Knapik JJ, Reynolds KL, Harman E. Soldier load carriage: historical, physiological, biomechanical, and medical aspects. Military Medicine. 2004;169(1):45–56. PubMed
  5. Murray-Leslie CF, et al. The knees and ankles in sport and veteran military parachutists. Annals of the Rheumatic Diseases. 1977. PMC
  6. Colvonen PJ, et al. Obstructive sleep apnea and posttraumatic stress disorder among OEF/OIF/OND veterans. Journal of Clinical Sleep Medicine. 2015;11(5):513–518. PubMed
  7. Breyer BN, et al. Sexual dysfunction in male Iraq and Afghanistan war veterans: association with posttraumatic stress disorder and other combat-related mental health disorders. Journal of Sexual Medicine. 2014;11(1):75–83. Wiley
  8. Edmondson D, et al. Posttraumatic stress disorder and risk for coronary heart disease: a meta-analytic review. American Heart Journal. 2013. PubMed
  9. American Diabetes Association. 12. Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes—2025. Diabetes Care. 2025;48(Suppl 1). Diabetes Care
  10. Patil JD, et al. The association between stress, emotional states, and tinnitus: a mini-review. Frontiers in Aging Neuroscience. 2023;15:1131979. Frontiers
  11. Young T, et al. Nasal obstruction as a risk factor for sleep-disordered breathing. Journal of Allergy and Clinical Immunology. 1997;99:S757–62. JACI